I am developing new chemical strategies for the synthesis of genetically-encoded macrocycle and bicycle libraries.

I did my doctoral research in synthetic organic chemistry under the supervision of Prof. Amit Basak in the department of chemistry, Indian Institute of Technology Kharagpur and post-doctoral research in chemical biology (especially on genetic code expansion) with Prof. Abhishek Chatterjee at the Chemistry Department in Boston College, U.S.A.

In my post doctoral research, I have developed a leucyl amino acyl tRNA synthetase (aaRS) which is orthogonal in mammalian cell and which can thereby site specifically introduce a huge range of cysteine based leucyl type unnatural amino acids (UAA) containing a broad range of bio-othogonal handles like terminal azides, alkynes, alkenes, thiols, alcohols, halides, keto functionalities etc. The incorporation of these UAA’s are proved by protein mass spectroscopy, fluorescent labeling followed by mass spectroscopy and in-gel-fluorescence.

My doctoral research was mainly focused on the area of diradical generating systems, especially their mechanisms and application towards natural product synthesis. I have synthesized a series of 1-indole-3-yl carbazoles by using Garratt-Braverman Cyclization as a key step and extended this strategy towards the synthesis of an advanced intermediate en route to the naturally occurring alkaloid pityriazole. I have studied the AChE (Acetylcholineesterase) inhibition with the synthesized indolocarbazoles. I have also worked on the total synthesis of marine alkaloid analogue 7’-desmethylkealiiquinone of kealiiquinone class. Following the methodology I have also made some advancement towards the synthesis of the natural products of kealiinine family. In the initial year of my Ph.D, I got acquainted with the field of asymmetric catalysis comprising 2, 2’-dihydroxy azobenzene templated peptide based ligand design, synthesis and their application in the asymmetric cyclopropanation of a, b-unsaturated carbonyl systems.

Daniel’s research focus involves the development of genetically encoded glycopeptide libraries displayed in M13 phages and the use of these libraries to develop ligands for Galectin-3 protein.

Daniel has obtained his Bsc in Biochemistry from the University of Havana, Cuba in 2008. After completing his undergraduate training, Daniel  worked for a Biotech company in Havana, Cuba (Heber-Biotec.Sa) working for to the Clinical Research division on custom biochemical analysis of biological samples from clinical trials of biotech drugs. In the fall 2013  he joined to the Graduate Program of the Department of Chemistry at the University of Alberta, and started to work within  Dr. Derda’s group  as a graduate student, since September,2013. Daniel has obtained a Visiting Research Scholar Position within Derda lab for the period October,2012  until April, 2013  as he was awarded with one of the Emerging Leaders for Americas Program scholarships, funded by the Canadian Bureau for International Education (CBIE) from Government of Canada.

Publications

P Kitov, D F Vinals , S Ng , K F Tjhung , and R Derda “Rapid, Hydrolytically Stable Modification of Aldehyde-terminated Proteins and Phage Libraries”, J. Am. Chem. Soc., 2014, 136, 8149–8152.

Yuki is developing new microfluidics and microdroplet-based technology for selection of genetically-encoded libraries, to study nucleation of supercooled water. Yuki is also supervising high school students in project related to heterogeneous and light-directed water nucleation. Yuki’s awards include Silver medal of iGEM2014 Competition, “Circular mRNA – the world’s longest protein”, October 2014, (Boston, USA) and Japan Student Services Organization (JASSO) Student Exchange Support Program Scholarship in September, 2015.

Jasmine was developing next generation glycan array technology called “liquid glycan array”.

Nick was developing new technologies and platforms for genetic encoding and presentation of diverse molecular structures on phage. He is applying these technologies to identify ligands for immune lectin DC-SIGN. The ultimate goal of this project is discovery of molecules and constructs that facilitate DC-SIGN-mediated delivery of antigens to dendritic cells, their internalization, processing and subsequent presentation to immune cells.

Publications from Derda Lab

1. Simon Ng, Nicholas James Bennett, Jessica Schulze, Nan Gao, Christoph Rademacher, Ratmir Derda* “Genetically-encoded Fragment-based Discovery of Glycopeptide Ligands for DC-SIGN“, Bioorg. & Med. Chem., 2018, 26(19), 5368-5377.

2. B. He, K. F. Tjhung, N. J. Bennett, Y. Chou, A. Rau, J. Huang, R. Derda*, ”Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing” Nat. Sci. Reports., 2018, 8, 1214

Jessica joined Derda Lab in 2012, when she was an 11th grade high-school student. She was working on portable bacteria cultures for detection of antibiotic resistance. In 2014, she won the 1st prize in Alberta in Sanofi BioGenius competition for her work on taxol-resistance of breast cancer cells in paper-based 3D cultures. During her undergraduate degree at the University of Alberta 2014-2018 she worked on development of ice-nucleating substances and light-triggered ice nucleating peptides.

Publications:

1.  E. Lin, A. Sikhand, Jessica M. Wickware, Y. Hao and R Derda*  “Peptide Microarray Patterning for Controlling and Monitoring Cell Growth” Acta Biomater., 2016, doi:10.1016/j.actbio.2016.01.028

2. Mohammad R. Jafari,  Hongtao Yu,  Jessica M. Wickware,  Yu-Shan Lin  and  Ratmir Derda*, ”Light Responsive Bicyclic Peptides” Org. Biomol. Chem., 2018, DOI: 10.1039/C7OB03178E 

Yubin was developing synthetic materials that control differentiation of Cancer Stem Cells (CSC) and promote or suppress epithelial-to-mesenchymal transitions (EMT).

Jessica was developing computational, data-mining and database tools to assist discoveries in genetically-encoded chemical libraries.

Carson’s project was development of strategies for delivery of drugs to and through the blood-brain barrier.

Publications:

1. V. Triana, R. Derda*, “Tandem Wittig / Diels-Alder Diversification of Genetically Encoded Peptide Libraries“, Org. Biomol. Chem., 2017, 15, 7869-7877

Samantha was working on translation and commercialization of the research from Derda lab. Samantha is a founding member of the 48Hour Discovery Inc.

Ali Chou was working on development of molecular diagnostics for detection of TB and TB-associated antibodies.

Publications while in Derda Lab:

1. K. F. Tjhung, F. Deiss, J. Tran, Y. Chou, R. Derda*, “Intra-domain phage display (ID-PhD) of peptides and mini-domain proteins censored from canonical pIII phage display“, 2015 Front. Microbiol. 6:340.

2. H. Anany, Y. Chou, S Cucic, S. Evoy, R. Derda, MW Griffiths*, “From Bits and Pieces to Whole Phage to Nanomachines: Pathogen Detection Using Bacteriophage“, Annu. Rev. Food Sci. Tech., 2017, 8.

3. Y. Chou, E. N. Kitova , M. Joe, R. Brunton, T. L. Lowary, J. S. Klassen, R. Derda*, “Genetically-encoded fragment-based discovery (GE-FBD) of glycopeptide ligands with differential selectivity for antibodies related to mycobacterial infections“, Org. Biomol. Chem, 2018, 16, 223 – 227

Susmita worked on developing genetically-encoded glycan array technology based on chemically modified bacteriophages (publication in preparation).

Andrei developed T7 Bacteriophages for detection of internalization events in mammalian cells.

Bifang developed computational / bioinformatic tools for next-generation sequencing data emanation from genetically-encoded selection experiments.

Publications while in Derda Lab:

B. He, K. F. Tjhung, N. J. Bennett, Y. Chou, A. Rau, J. Huang, R. Derda*, “Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing” Sci. Reports., 2018, accepted

Reza Jafari has received his PharmD degree from Shiraz University of Medical Sciences, Shiraz, Iran. He joined the Derda lab in September 2010 to develop genetically-encoded libraries of light-responsive small molecules. Reza’s notable awards include Provost Doctoral Entrance Award, University of Alberta, 2010 and 2011, and AITF graduate Student Fellowship since May 2013.  Reza is professional photographer and sells his prints here and there as a hobby.

Publications while in Derda Lab:

7. S. Kalhor-Monfared,   MR Jafari,   J. T. Patterson,   P. I. Kitov,   J. J. Dwyer,   J. J. Nuss and R. Derda  “Rapid Biocompatible Macrocyclization of Peptides with Decafluoro-diphenylsulfone” Chem. Sci., 2016, 7, 3785-3790.

6. MR Jafari, J. Lakusta, R. J. Lundgren, and R Derda*  “Allene Functionalized Azobenzene Linker Enables Rapid and Light-Responsive Peptide Macrocyclization” Bioconj. Chem., 2016, 27, 509–514

5. MR Jafari, Lu Deng, S Ng, W Matochko, K Tjhung, A Zeberof, A Elias, John S. Klassen, R Derda* “Discovery of light-responsive ligands through screening of light-responsive genetically-encoded library“, ACS Chem. Biol., 2014, 9, 443–450 (front cover)

4. S Ng, MR Jafari, W Matochko, R Derda* “Quantitative Synthesis of Genetically Encoded Glycopeptide Libraries Displayed on M13 Phage” ACS Chem. Biol., 2012, DOI: 10.1021/cb300187t23.

3. W Matochko, S Ng, MR Jafari, J Romaniuk, SKY Tang, R Derda* “Uniform amplification of phage display libraries in monodisperse emulsions“, Methods, 2012, 10.1016/j.ymeth.2012.07.012

2. S Ng, MR Jafari, R Derda* “Bacteriophages and Viruses as a Support for Organic Synthesis and Combinatorial Chemistry“, 2011, ACS Chem. Biol. 7, 123.

1. R. Derda,* SKY Tang, SC Li, S Ng, WL Matochko, MR Jafari “Diversity of Phage-Displayed Libraries of Peptides During Panning and Amplification” Molecules 2011, 16, 1776-1803.

Yvette was in charge of SyntArray.com — a service in Derda group that produces peptide microarrays for protein and cell-based assays

Publications while in Derda Lab:

1. F. Deiss, Y. Yang, R. Derda* Parallel Syntheses of Peptides on Teflon-Patterned Paper Arrays (SyntArrays). Methods. Mol. Biol. 2016, 1368, 249-71

2. F. Deiss#, Y. Yang#, W. Matochko, R. Derda* “Heat-enhanced peptide synthesis on Teflon-patterned paper“, Org. Biolmol. Chem. DOI: 10.1039/C6OB00898D  (# – equal contribution)

Simon received his BSc (Hons) from Nanyang Technological University in Singapore majoring in Chemistry & Biological Chemistry. After completing his undergraduate training, he moved to University of Alberta and joined group of Ratmir Derda as a Ph.D. student in September 2010. His project involved modification of libraries of peptides displayed on bacteiophages to genetically-encoded and amplifiable libraries of bioactive molecules. Simon’s awards include Provost Doctoral Entrance Award, University of Alberta (2010), and Margaret Thomson Memorial Prize in Chemistry (2011), Departmental RA Award (2011) and Alberta Innovates Graduate Student Scholarship (2012).

Publications while in Derda Lab:

10. S. Ng and R Derda*  “Phage-displayed Macrocyclic Glycopeptide Libraries” Org. Biomol. Chem., 2016, 14, 5539-5545

9. KF Tjhung, S. Ng, PI Kitov, EN Kitova, L Deng, JS Klassen, and R Derda*  “Silent Encoding of Chemical Post-Translational Modifications in Phage-Displayed Libraries“, J. Am. Chem. Soc., 2016, 138, 32–35.

8. S. Ng, E. Y. Lin, PI Kitov, KF Tjhung, OO Gerlits, L Deng, B Kasper, A Sood, BM Paschal, P Zhang, CC Ling, JS Klassen, CJ Noren, LK Mahal, RJ Woods, L Coates, and R Derda*  “Genetically-encoded Fragment-based Discovery of Glycopeptide Ligands for Carbohydrate-binding Proteins“, J. Am. Chem. Soc., 2015, 137, 5248–5251

7. P Kitov, D F Vinals , S Ng , K F Tjhung , and R Derda “Rapid, Hydrolytically Stable Modification of Aldehyde-terminated Proteins and Phage Libraries”, J. Am. Chem. Soc., 2014, 136, 8149–8152.

6. L Liu, N Jalili, A Baergen, S Ng, J Bailey, R Derda, JS Klassen* “Energetics of Fluorine Bonding in Protein-Fatty Acid Complexes. Insights from Gas-Phase Measurements“, Journal of The American Society for Mass Spectrometry, 2014, 25, (5), 751-757

5. MR Jafari, Lu Deng, S Ng, W Matochko, K Tjhung, A Zeberof, A Elias, John S. Klassen, R Derda* “Discovery of light-responsive ligands through screening of light-responsive genetically-encoded library“, ACS Chem. Biol., 2014, 9, 443–450 (front cover)

4. S Ng, MR Jafari, W Matochko, R Derda* “Quantitative Synthesis of Genetically Encoded Glycopeptide Libraries Displayed on M13 Phage” ACS Chem. Biol., 2012, 7 (9), 1482–1487. Cover Story of September Issue

3. W Matochko, S Ng, MR Jafari, J Romaniuk, SKY Tang, R Derda* “Uniform amplification of phage display libraries in monodisperse emulsions“, Methods, 2012, 10.1016/j.ymeth.2012.07.012

2. S Ng, MR Jafari, R Derda* “Bacteriophages and Viruses as a Support for Organic Synthesis and Combinatorial Chemistry“, 2011, ACS Chem. Biol. 7, 123.

1. Derda R, Tang SKY, Li SC, Ng S, Matochko W, Jafari MR. “Diversity of Phage-Displayed Libraries of Peptides During Panning and Amplification” Molecules 2011, 16, 1776-1803.

Publications while in Derda Lab:

1. S. Kalhor-Monfared,   M. R. Jafari,   J. T. Patterson,   P. I. Kitov,   J. J. Dwyer,   J. J. Nuss and R. Derda  “Rapid Biocompatible Macrocyclization of Peptides with Decafluoro-diphenylsulfone” Chem. Sci., 2016, 7, 3785-3790.

Publications while in Derda Lab:

1. KF Tjhung,# JM. Douglas,# and R. Derda*  “Genetically-encoded libraries produced in monodisperse emulsions” in preparation.

In 2006, Frédérique received the degree of Ingénieur from the National Engineering School of Physics and Chemistry of Bordeaux (ENSCPB), and a Science and Technology Master’s degree in Chemistry from the University of Bordeaux, France. She went on with a Ph.D. of the University of Bordeaux, in Chemistry-Physics, received in 2009 with high distinction, after three years of research under the supervision of Neso Sojic in the Analytical Nanosystems group. She developed optoelectrochemical micro- and nano-sensor arrays for bioanalytical applications at the tip of optical fiber bundles. (French Thesis) During her doctoral research, she has also been a visiting PhD student in various research groups including David R. Walt’s group (Tufts University, Medford, MA, USA), Paolo Ugo’s group (University of Venice, Italy), and Paolo Pastore’s group (University of Padova, Italy). She pursued her research activities as a postdoctoral fellow in the Whitesides group (Harvard University, Cambridge, MA, USA) developing, in particular, low-cost paper-based electrochemical diagnostic devices. In 2012, she joined the Derda group, where she was supported by Rising Star in Global Health Award to develop paper-based bio-analytical platforms for applications in organic synthesis, cell culture and portable culture of bacteria.

Publications while in Derda Lab:

6. F. Deiss,# Y. Yang,# W. L. Matochko, R. Derda*  “Heat-enhanced peptide synthesis on Teflon-patterned paper“, Org. Biolmol. Chem. 2016, 14, 5148-5156

5. F. Deiss, Y. Yang, R. Derda* Parallel Syntheses of Peptides on Teflon-Patterned Paper Arrays (SyntArrays). (book chapter) Methods. Mol. Biol. 2016, 1368, 249-71

4. Deiss, F.; Huacca, MF.; Bal, J.; Tjhung, KF.; Derda R Antimicrobial susceptibility assays in paper-based portable culture devices, Lab Chip, 2014, 14, 167-171, (back cover)

3. S. Burnham, J. Hu, H. Anany, L. Brovko, F. Deiss, R. Derda, M. W. Griffiths*, “Towards rapid on-site phage-mediated detection of generic Escherichia coli in water using luminescent and visual readout“. Anal Bioanal Chem., 2014, 406, (23), 5685-5693

2. Deiss, F; Matochko, WL.; Govindasamy, N.; Lin, EY.; Derda, R.  Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays, Angewandte Chemie, 2014, DOI: 10.1002/anie.201402037 (featured as ‘Hot Article’ and on back cover)

1. K. F. Tjhung, F. Deiss, J. Tran, Y. Chou, R. Derda*, “Intra-domain phage display (ID-PhD) of peptides and mini-domain proteins censored from canonical pIII phage display“, 2015 Front. Microbiol. 6:340.

Misc. Awards

Grand Challenges Canada – Stars in Global Health, round 6; seed grant of $112,000 for 18 months (one of the 61 projects selected from over 750 applications); started in April 2014.video of the proposal

Wadim Matochko obtained his B.Sc. in Biochemistry from the University of Winnipeg in 2007. From 2007 to 2008, Wadim worked for a biopharmaceutical company (Viventia) investigating antibodies for their anti-cancer activities. In 2008, under the supervision of Athar Ata, he isolated and characterized natural products from medicinally important plants. Based on this research he obtained his M.Sc. in Organic Chemistry from the University of Manitoba. In 2010 he entered the Chemistry program at the University of Alberta under the supervision of Ratmir Derda. His research will focus on asymmetric cell division.

Publications while in Derda Lab:

11.  F. Deiss,# Y. Yang,# W. L. Matochko, R. Derda*  “Heat-enhanced peptide synthesis on Teflon-patterned paper“, Org. Biolmol. Chem. 2016, 14, 5148-5156

10. (Book chapter) W. L. Matochko, R. Derda*, “Next-Generation Sequencing of Phage-Displayed Peptide Libraries“, Methods in Molecular Biology, Volume 1248, 2015, pp 249-266

9. F Deiss, WL Matochko, N Govindasamy, E Y Lin and R Derda “Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays”, Angewandte Chemie, 2014, 53, 6374–6377. (featured as ‘Hot Article’ and on back cover)

8. WL Matochko, SC Li, SKY Tang, R Derda * “Prospective identification of parasite sequences in phage display screens“  Nuc. Acid. Res., 2014, 42, (3), 1784-1798.

7. BM Scott, WL Matochko, RF Gierczak, V Bhakta, R Derda, WP Sheffield* “Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin“, PLoS One, 2014, 9, (1), e84491

6. MR Jafari, Lu Deng, S Ng, WL Matochko, K Tjhung, A Zeberof, A Elias, John S. Klassen, R Derda* “Discovery of light-responsive ligands through screening of light-responsive genetically-encoded library“, ACS Chem. Biol., 2014, 9, 443–450 (front cover)

5. W Matochko, R Derda “Error analysis of deep sequencing of phage libraries: Peptides censored in sequencing” Comput Math Methods Med. (Phage Display Bioinformatics Issue), 2013, Vol. 2013, Article ID 491612

4. S Ng, MR Jafari, WL Matochko, R Derda* “Quantitative Synthesis of Genetically Encoded Glycopeptide Libraries Displayed on M13 Phage” ACS Chem. Biol., 2012, DOI: 10.1021/cb300187t23.

3. WL Matochko, S Ng, MR Jafari, J Romaniuk, SKY Tang, R Derda* “Uniform amplification of phage display libraries in monodisperse emulsions“, Methods, 2012, 10.1016/j.ymeth.2012.07.012

2. WL Matochko, K Chu, B Jin, SW Lee, G Whitesides, R Derda* “Deep sequencing analysis of phage libraries using Illumina“, Methods, 2012, 10.1016/j.ymeth.2012.07.006

1. Derda R, Tang SKY, Li SC, Ng S, Matochko WL, Jafari MR. “Diversity of Phage-Displayed Libraries of Peptides During Panning and Amplification” Molecules 2011, 16, 1776-1803.

Publications while in Derda Lab:

1. S. Ng, EY Lin, PI Kitov, KF Tjhung, OO Gerlits, L Deng, B Kasper, A Sood, BM Paschal, P Zhang, CC Ling, JS Klassen, CJ Noren, LK Mahal, RJ Woods, L Coates, and R Derda*  “Genetically-encoded Fragment-based Discovery of Glycopeptide Ligands for Carbohydrate-binding Proteins“, J. Am. Chem. Soc., 2015, 137, 5248–5251

2. F Deiss, W L Matochko, N Govindasamy, EY Lin and R Derda “Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays”, Angewandte Chemie, 2014, 53, 6374–6377. (featured as ‘Hot Article’ and on back cover)

3. M. Pan, L. Rosenfeld, M. Kim, M. Xu, EY Lin, R. Derda and S. K. Y. Tang “Fluorinated Pickering Emulsions Impede Interfacial Transport and Form Rigid Interface for the Growth of Anchorage-Dependent Cells” ACS Appl. Mater. Interfaces, 2014, 6, 21446–21453

4. EY Lin, A. Sikhand, J. Wickware, Y. Hao and R Derda*  “Peptide Microarray Patterning for Controlling and Monitoring Cell Growth” Acta Biomater., 2016, 34, 53–59

Publications from Derda Lab

1. EY Lin, A. Sikhand, J. Wickware, Y. Hao and R Derda*  “Peptide Microarray Patterning for Controlling and Monitoring Cell Growth” Acta Biomater., 2016, 34, 53–59

Katrina completed degree in Pharmacology at the University of Alberta. She was a full-time member of the Derda research group from May 2011 to July 2014 working on genetic and chemical modification of filamentous M13 phage to make it a useful tool for chemical biology and development of low-cost diagnostics.

Some of her awards include the Jason Lang Scholarship, the University of Alberta Academic Excellence Scholarship, the Faculty of Science Academic Excellence Scholarship, AIHS Summer Fellowship (2012-2014), NSERC USRA summer fellowship (2013) and NSERC Masters Fellowship (2014, declined).

Publications while in Derda Lab:

1. F Deiss, MF Huacca, J Bal, K Tjhung, R Derda* “Antimicrobial susceptibility assays in paper-based portable culture devices“, Lab Chip, 2014, 14, 167-171, (back cover)

2. MR Jafari, Lu Deng, S Ng, W Matochko, KF Tjhung, A Zeberof, A Elias, John S. Klassen, R Derda* “Discovery of light-responsive ligands through screening of light-responsive genetically-encoded library“,  ACS Chem. Biol., 2014, 9, 443–450 (front cover)

3. K. F. Tjhung, S. Burnham, H. Anany, M. W. Griffiths and R. Derda “Rapid enumeration of phage in monodisperse emulsions“, Anal. Chem., 2014, 86, 5642–5648.

4. P Kitov, D F Vinals , S Ng , K F Tjhung, and R Derda “Rapid, Hydrolytically Stable Modification of Aldehyde-terminated Proteins and Phage Libraries”, J. Am. Chem. Soc., 2014, 136, 8149–8152.

5. S. Ng, E. Y. Lin, PI Kitov, KF Tjhung, OO Gerlits, L Deng, B Kasper, A Sood, BM Paschal, P Zhang, CC Ling, JS Klassen, CJ Noren, LK Mahal, RJ Woods, L Coates, and R Derda*  “Genetically-encoded Fragment-based Discovery of Glycopeptide Ligands for Carbohydrate-binding Proteins“, J. Am. Chem. Soc., 2015, 137, 5248–5251

6. K. F. Tjhung, F. Deiss, J. Tran, Y. Chou, R. Derda*, “Intra-domain phage display (ID-PhD) of peptides and mini-domain proteins censored from canonical pIII phage display“, 2015 Front. Microbiol. 6:340.

7. K. F. Tjhung, S. Ng, PI Kitov, EN Kitova, L Deng, JS Klassen, and R Derda*  “Silent Encoding of Chemical Post-Translational Modifications in Phage-Displayed Libraries“, J. Am. Chem. Soc., 2016, 138, 32–35.

Publications while in Derda Lab:

1. F Deiss, MF Huacca, J Bal, K Tjhung, R Derda* “Antimicrobial susceptibility assays in paper-based portable culture devices“, Lab Chip, 2014, 14, 167-171, (back cover)

2. MF Huacca, A Wu, E Szepesvari, P Rajendran, N Kwan-Wong, A Razgulin, Y Shen, J Kagira, R Campbell, R Derda* “Portable cultures for phage and bacteria made of paper and tape” Lab Chip, 2012, 12, 4269-4278

Publications while in Derda Lab:

1. F Deiss, MF Huacca, J Bal, K Tjhung, R Derda* “Antimicrobial susceptibility assays in paper-based portable culture devices“, Lab Chip, 2014, 14, 167-171, (back cover)

Jessica joined the Derda research group initially as a volunteer in early 2013 and continued onwards being a Chem 401 and Chem 403 student. Her project involved modifying bacteriophage in order to create libraries of protease resistance variants.

Jessica’s Awards include the University of Alberta Academic Excellence Scholarship (2010) and the Undergraduate Research Stipend (2013).

Publications while in Derda Lab::

1. K. F. Tjhung, F. Deiss, J. Tran, Y. Chou, R. Derda*, “Intra-domain phage display (ID-PhD) of peptides and mini-domain proteins censored from canonical pIII phage display“, 2015 Front. Microbiol. 6:340.

Publications while in Derda Lab::

1. F Deiss, W L Matochko, N Govindasamy, E Y Lin and R Derda “Flow-Through Synthesis on Teflon-Patterned Paper To Produce Peptide Arrays for Cell-Based Assays”, Angewandte Chemie, 2014, 53, 6374–6377.

Publications while in Derda Lab::

1. W Matochko, S Ng, MR Jafari, J Romaniuk, SKY Tang, R Derda* “Uniform amplification of phage display libraries in monodisperse emulsions“, Methods, 2012, 58 (1), 18-27.

Publications while in Derda Lab::

1. W Matochko, K Chu, B Jin, SW Lee, G Whitesides, R Derda* “Deep sequencing analysis of phage libraries using Illumina“, Methods, 2012, 58 (1), 47–55